When Jamie Miller and her wife, Alex Kanai, try to save their failing marriage by going on a canoe trip in rural Missouri, they find themselves stranded after an accident. Alex breaks her leg during a canoe flip and they must slowly make their way to the nearest small town for help. Upon arriving they find it has been overrun by virus-infected “Heps” and extreme right wing local militias who are battling them. The leader of one of the groups, "Big John Gruber", shuttles them to safety at his
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